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Before you take any serotonin supplement, it’s important to understand a little bit about them and especially how they work together.Sometimes there are vital synergistic relationships between these various serotonin boosting substances.

Conversely, there are times when these supplements can react adversely with medications or other serotonin supplements, and you need to know about those, too.It’s believed that low serotonin is the underlying cause of depression.Selective serotonin reuptake inhibitors (SSRIs) such as Paxil, Prozac, Zoloft, Celexa, and Lexapro are used by millions to relieve symptoms of depression by increasing brain levels of serotonin.But SSRIs can have serious side effects and don’t work for everyone, possibly up to 40 percent of those who try them (1).Some research shows they work no better than a placebo (2).